domenica 14 ottobre 2018

Manlio Vinciguerra CV

Born in Catania (Italy) on May 5th 1976
Italian Nationality

2017 - current Principal Investigator, International Clinical Research Center, Brno, Czech Republic.

2013 - 2016 Principal Research Associate, Institute for Liver and Digestive Health, University College London, London, UK.
2015 - 2016 Reader, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
2011 - 2013 Principal Investigator, Institute of Hepatology, Foundation for Liver Research, London, UK.
2008 - 2011 Post-Doctoral Fellow, European Molecular Biology Laboratory, Italy - Germany.
2005 – 2008 Post-Doctoral Fellow, University of Geneva Medical School, Geneva, Switzerland.

2017 - current Honorary Senior Research Associate, University College London (UCL), London, UK.
2017 - October Visiting Scientist, Mayo Clinic, Rochester, USA.
2014 - current Visiting Scientist, Tallinn Technological University, Tallinn, Estonia.
2014 - October&November Visiting Scientist, School of Medicine, Tottori University, Yonago, Japan.
2012 - 2015 Staff Scientist, IRCCS “Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
2012 - December&January Visiting Scientist, University of Southern California, Los Angeles, USA.

Foundation for Liver Research 2011-2012 £60 K PI
UCL seed fund 2013-2015 £30 K PI
AIRC 2013-2015 €240 K PI
Italian Ministry of Health (Young Researcher Program) 2013-2015 €329 K co-PI
Italian Ministry of Health (Grant Research Program) 2013 €15 K co-PI
Rottapharm Madaus (Pharma, Italy) 2015 €20 K PI
E3Bio (Pharma, UK) 2015 £10 K PI
Astex Pharmaceuticals (Pharma, US) 2015 £13 K PI
NTU Quality Research funds 2015 £30 K PI
NTU Strategic Investment Funds (Epigenetics) 2015 £110 K PI
SoMoPro (EU/Czech Republic) 2016 €200 K PI (declined)
OP VVV MAGNET- Key Incoming Researcher - Excellent Research Team (EU/Czech Republic) 2016-2022 €6.5M PI
H2020 European Human Biomonitoring Initiative (acronym HBM4EU), leader of a Work Package 2017-2022 €115K co-PI
H2020-EU.4.a. - Teaming of excellent research institutions and low performing RDI regionsCETOCOEN Excellence Project ID: 763677, 2017-2018 €32.4K co-PI
AZV CR (Czech Health Research Council) €347K PI
COST Action Proposal OC-2017-1-22353 Catalysing transcriptomics research in cardiovascular disease €8K co-PI
OP VVV ENOCH- Excellent Research (EU/Czech Republic) 2018-2023 €400K co-PI
TOTAL = £253K + €8.1M = ~€8.4M

Jan 2001 – Dec 2004 PhD, Department of Internal Medicine, University of Geneva Medical School, Geneva, Switzerland. PhD awarded on September 23rd 2004 with full marks.
2001 MSc, University of Geneva Medical School, Geneva, Switzerland.
Oct 1999 – Oct 2000 Laboratory training at the Department of Biomedical Sciences, University of Catania, Italy.
Sept 1994 - July 1999 Degree in Biomedical Sciences, with full marks (110/110 cum laude) at the University of Catania, Italy. Experimental work carried out at St. Radboud Hospital, Nijmegen, The Netherlands.
July 1994 High school diploma (science), Catania, Italy.

Epigenetics (DNA methylation, histone variants) (active, 15 papers)
Cell differentiation (active, 78 papers)
Mice models of diseases (active, 40 papers)
Gut microbiota, nutrition and aging (active, 21 papers)
Liver diseases, from fatty liver to liver cancer (active, 63 papers)
Population studies (active, 4 papers)

Heart diseases, growth factors and injury (inactive, 14 papers)
Circadian clock (inactive, 24 papers)
Colorectal cancer (inactive, 7 papers)
Skeletal muscle physiology (inactive, 7 papers)
Renal physiology (inactive, 14 papers))

2016 South Moravian Program for Distinguished Researchers (SoMoPro) (declined)
2016 UCL - Santander (Brazil) Travel Grant
2014 UCL - Santander (Brazil) Travel Grant
2012 United European Gastroenterology Week (UEGW) Travel Grant
2011 French Foundation for Medical Research (FRM) fellowship (declined).
2011 Swiss National Science Foundation (SNSF) Assistant Professorship (finalist).
2008 EMBL Interdisciplinary POst-Doctoral (EIPOD) fellowship.
2006 EASL Young Investigator Travel Bursary.
2005 Post-doctoral fellowship funded by Swiss National Fund for Research (CH).
2005 Post-doctoral stage funded by Telethon (IT).
2002 Fondation Ernst and Louise Schmidheiny travel bursaries (CH).
2001 PhD fellowship funded by Swiss National Fund for Research (CH).
1998 Socrates fellowship (European Union).

2018 - current member of Board of the PhD program, Medical Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
2017 - current Leader of Kardiovize Brno 2030 Governing Board, ICRC,Brno, Czech Republic.
2017 - current Assistant Professor, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Practical course of Histology to medical students at their 1st year and 2nd year.
2015 - 2016 Leader of Epigenetics of Nutrition MSc module, Scuola Superiore di Catania, University of Catania, Italy.
2015 - 2016 Leader of Scientific Analysis, Review and Presentation (eSARP) module, NTU, UK.
2015 - 2016 Leader of Biology of Disease MSc module, NTU, UK.
2015 - 2016 Leader of Cancer and Heart disease MSc module, NTU, UK.
2015 - 2016 Lecturer in Cell Signalling&Cancer module, NTU, UK.
2015 - 2016 Lecturer in Living systems, NTU, UK.
2014 – 2015 Lecturer of Epigenetics at the Applied Medical Sciences MSc, UCL.
2014 – 2015 member of the UCL-Santander project for scientific exchange between UCL and Brazilian Universities.
2013 - 2015 Personal Tutorship for UCL-Division of Medicine MSc courses: Clinical Drug Development, Clinical Public Health Nutrition, Eating Disorders and Clinical Nutrition and Drug Design.
2013 - 2016 UCL-Biomedical Research Centre (BRC) Infection, Immunity and Inflammation Programme Faculty Member, London, UK.
2013 - 2015 coaching activity at the Italian National Order of Biologists (ONB,, Italy.
2011 - 2012 collaborator, at the School of Sciences, Birkbeck College, London, UK.
2009 - 2011 collaborator of the European Learning Laboratory for the Life Sciences [ELLS] – EMBL, Monterotondo, Italy.
2009 - 2011 Representative of Post-doctoral Association for EMBL Monterotondo Outstation.
2006 - 2008 Practical course of Histology to medical students at their 1st year and 2nd year.
Problem solving-based learning course (PBL) on Cell Growth and Aging to medical students at their 2nd year. Faculty of Medicine, University of Geneva, Geneva, Switzerland.

2018 Cancer Epigenetics Society
2016 Via Academy - Top Italian Scientists
2015 International Cell Senescence Association (ICSA)
2012 European Association for the Study of Diabetes (EASD)
2011 European Association for the Study of the Liver (EASL)
2007 Swiss Society for Endocrinology and Diabetology
2006 Swiss-Italian (Ticinese) Society of Biomedical and Chemical Sciences (STSBC)
2005 Dulbecco Telethon Institute (DTI)
2004 Swiss-Italian Association for Biomedical Research (ASIRB)
2004 Swiss Society of Biochemistry (USGEB)
2003 American Society of Cell Biology (ASCB)
2001 Italian National Order of Biologists

• Italian language (Mother tongue)
• English language (Fluent)
• French language (Fluent)
• Spanish language (Proficient)
• German language (Elementary)
• Estonian language (Elementary)

Journals (ad hoc)
Acta Diabetologica; Acta Pharmacologica Sinica; Acta Physiologica; Adv Clin Chem; Advanced Drug Delivery Reviews; Age; Aging Cell; Aging Research Reviews; American Journal of Clinical Nutrition; Angiology; Annals of Gastroenterology; Annals of Medicine; Antioxidant & Redox Signaling; Appl Physiol Nutr Metab; Biochimica Biophysica Acta (BBA)- Molecular Basis of disease; Biochimie; Biogerontology; Biomed Res Int; BMC Cancer; BMC Gastroenterology; Brain Research; Cancer Cell International; Cancer Medicine; Cancer Research; Can J Physiol Pharmacol; Cardiovascul Diabetol; Cell; Cell Communication and Signaling; Cell Cycle; Cell Death & Disease; Cellular Gastroenterology & Hepatology; Cell Metabolism; Cellular and Molecular Life Sciences; Cell Oncology; Chronobiology International; Circulation Research; Clin Exp Pharmacol Physiol; CNS & Neurological Disorders - Drug Targets; Current Cancer Therapy Reviews; Current Clinical Pharmacology; Current Pharmaceutical Design; Diabetologia; Digestive and Liver Disease; Diseases; EBioMedicine; eLife; Endocrine-Related Cancer; Epigenetics; Epigenomics; European Journal of Histochemistry; European Journal of Pharmacology; Experimental Molecular Pathology; Frontiers in Endocrinology; Frontiers in Mol Neurosci; Frontiers in Physiol; Future Oncology; Journal of Cellular and Molecular Medicine; Journal of Clinical Epidemiology; Journal of Clinical Medicine; Journal of Hepatology; Journal of Histology; Journal of Inflammation; Journal of Molecular Medicine; Genes, Chromosomes and Cancer; Gerontology; Gut; Hepatology; Hepatology Research; Hepatoma Research; Human Mutation; FASEB Journal; Fibrogenesis & Tissue Repair; Frontiers in Endocrinology; Frontiers in Neurosciences; Frontiers in Physiology; International Journal of Genetics and Gene Therapy; International Journal of Immunopathology and Pharmacology; International Journal of Molecular Sciences; International Journal of Obesity; International Reviews in Cellular and Molecular Biology; Journal of Inflammation; Journal of Investigative Medicine; Journal of Nutrition and Metabolism; Journal of Nutritional Biochemistry; Journal of Steroid Biochemistry and Molecular Biology; Life Sciences; Mammalian Genome; Medical Sciences; Mediators of Inflammation; Medicinal Research Reviews; Molecular Brain; Molecular Cancer Research; Molecular Cellular Endocrinology; Molecular Medicine; Molecular Therapy; Molecules; Nutrients; Nutrition; Nutr Metab Cardiovasc Dis; Nutrition Research; Oncotarget; OncoTargets and Therapy; Oxidative Medicine and Cellular Longevity; Physiology&Behaviour; PLoS ONE; PNAS; Prostaglandins and Other Lipid Mediators; Scandinavian Journal of Immunology; Scientific Reports; TheScientificWorldJournal; Toxicol Appl Pharmacol; Translational Psychiatry; Translational Research; Trends Endocrinology Metabolism; Tumour Biol; Vascul Pharmacol; World J Gastroenterology; World J Hepatology

• Horizon 2020
• European Cooperation in Science and Technology (COST)
• European Research Council (ERC) Starting Grants • Human Frontiers Science Program (HFSP), EU member states
• Medical Research Council (MRC) - United Kingdom
• BBSRC - United Kingdom
• Wellcome Trust - United Kingdom
• Canadian Institutes of Health Research, Institute of Genetics (CIHR-IG), Canada
• Fonds de la Recherche en Santé du Québec (FRSQ), Canada
• The French National Research Agency (ANR), France
• Federal Ministry of Education and Research (BMBF), Germany
• Institute of Health Carlos III (ISCIII), Spain
• Hungarian Scientific Research Fund (OTKA), Hungary
• Research Grants Council, Hong Kong, China
• National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), United Kingdom
• ERASysAPP - ERA-Net for Systems Biology Applications, EU member states
• Wellington Medical Research Foundation (WMRF), New Zealand
• WHRI-ACADEMY (COFUND Marie Curie) Fellowship Programme, United Kingdom
• World Cancer Research Fund International (WCRF), United Kingdom
• Netherlands Organisation for Scientific Research (NWO), Netherlands
• Austrian Science Fund (FWF), Austria
Other • Associate Faculty Member (AFM), Physiogenomics, Faculty of 1000 (

• Review Editor, Elife:
• Academic Editor, PLoS ONE:
• Associate Editor, BMC Gastroenterology:
• Editorial Board, Butrients:
• Editorial Board, Int J Mol Sci:
• Review Editorial Board of Frontiers in Gastrointestinal Sciences - Frontiers in Physiology.
• Research Topic Editor, Frontiers in Genetics, "Role of Epigenetic Modifications on Diet-Induced Metabolic Diseases", 2018
• Guest Editor of the special issue "Adipokines as Biomarkers in Health and Disease", published on Disease Markers. 2018.
• Guest Editor of the special issue "Paracrine mechanisms, signaling and epigenetics in repairing damaged tissue", published on Recent Patents on Regenerative Medicine (RPRM), Bentham Science Publishers (, 2013.
• Guest Editor of the special issue "PPARs and gastrointestinal cancer", published on PPAR Research, 2012.

• at XIV Diagnostic, Predictive, and Experimental Oncology Days - Translational Cancer Research - November 20, 2018, Olomouc, Czech Republic.
• at XIII Diagnostic, Predictive, and Experimental Oncology Days - Translational Cancer Research - November 29, 2017, Olomouc, Czech Republic.
• member of the Scientific Advisory Committee EASYM (European Association for System Medicine) Conference 2018.
• at 2016 Obesity Summit, April 12-14, 2016, London, UK.
• at AMEC 2014 2nd AESTHETIC & Anti-Aging Medicine European Congress. Session: Metabolism linked to cancer, October 25, 2014, Paris, France.
• at Ettore Majorana Foundation and Centre for Scientific Culture, 79th Workshop: Interventions to slow aging in humans: Are we ready?, October 8-13, 2013, Erice, Italy.
• at International Association for Gerontology and Geriatrics (IAGG), “Tissue Maintenance and Stem Cell in Ageing”, June 22-27, 2013, Seoul, South Korea.
• at GORDON-KENAN Research Seminar on Biology of Aging, August 21-22, 2010, Les Diablerets, Switzerland.

CONFERENCES ATTENDED (abstracts&posters)
• 90 at international Conferences in Europe (61), United States (25), Brazil (1), Mexico (1), Thailand (1) and Japan (1).

@ Conferences
• 28 in Italy (6), France (5), Holland (2), UK (2), Austria (2), Germany (3), Spain (1), Croatia (1), Switzerland (1), Mexico (1), Thailand (1), Czech Republic (1), USA (1) and Brazil (1).

@ Universities/Research Institutions/Companies
• 62 Invited Lectures in Italy (16), UK (9), France (5), Spain (4), Switzerland (4), Estonia (3), Holland (3), Brazil (3), Germany (2), USA (3), Czech Republic (4), Georgia (2), Japan (1), Argentina (1), India (1) and Singapore (1).

Publications, indexed on Pubmed/Medline
P:original research paper
E: editorial

1. Feraille, E, Mordasini, D, Gonin, S, Deschenes, G, Vinciguerra, M, Doucet, A, Vandewalle, A, Summa, V, Verrey, F, Martin, P.Y. (2003) Mechanism of control of Na,KATPase in principal cells of the mammalian collecting duct. Ann. N. Y. Acad. Sci. 986, 570-578. R
2. Vinciguerra, M, Deschenes, G, Hasler, U, Mordasini, D, Rousselot, M, Doucet, A, Vandewalle, A, Martin, PY, Feraille, E. (2003) Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells. Mol. Biol. Cell. 14, 2677-2688. P
3. Vinciguerra, M, Arnaudeau, S, Hasler, U, Mordasini, D, Rousselot, M, Vandewalle, A, Martin, PY, Feraille, E. (2004) Extracellular hypotonicity increases Na,K-ATPase cell surface expression via enhanced apical Na+ influx in collecting duct principal cells. J. Am. Soc. Nephr. 15. 2537-2547. P
4. Vinciguerra, M, Vandewalle, A, Feraille, E (2005) Hormonal Control of Na,K-ATPase in mammalian collecting duct principal cells. Semin. Nephr. 25. 312-321. R
5. Hasler, U, Vinciguerra, M, Vandewalle, A, Martin, PY, Feraille, E. (2005) Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells. J. Am. Soc. Nephr. 16. 1571-1582. P
6. Vinciguerra, M, Hasler, U, Mordasini, D, Rousselot, M, Capovilla, M, Ogier-Denis, E, Vandewalle, A, Martin, PY, Feraille, E. (2005). Cytokines and Sodium Induce PKA dependent Cell-surface Recruitment of Na,K-ATPase via Dissociation of NFκB/IκB/PKAc Complex in Collecting Duct Principal Cells. J. Am. Soc. Nephr. 16. 2576-2585. P
7. Vinciguerra, M, Foti, M (2006) PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signaling. Arch. Physiol. Biochem. 112 (2). 89-104. R
8. De Gottardi, A, Vinciguerra, M, Sgroi, A, Nguyen, T, Ravier Dell’Antonia, F, Pazienza, V, Pugnale, P, Trono, D, Negro, F, Foti, M, Hadengue, A, (2007) Microarray analyses and molecular profiling of induction of steatosis in immortalized human hepatocytes. Lab. Invest. 87(8). 792- 806. P
9. Cederroth, CR, Vinciguerra, M, Kuhne, F, Madani, R, Klein, M, James, RW, Doerge, DR, Visser, JT, Foti, M, Rohner-Jeanrenaud, F, Vassalli, JD, Nef, S, (2007) A phytoestrogen rich diet increases energy expenditure and decreases adiposity in mice. Environ. Health. Persp. 115(10). 1467-73. P
10. Vinciguerra, M, Veyrat-Durebex, C, Moukil, MA, Rohner-Jeanrenaud F, Foti, M, (2008) PTEN downregulation by FFA in hepatocytes via a NF-kBp65/mTOR-dependent mechanism triggers steatosis. Gastroenterology. 134(1). 268-280. P
11. Vinciguerra, M, Foti, M (2008) PTEN at the crossroad of metabolic diseases and cancer in the liver. Ann. Hepatol. 7(3). 192-199. R
12. Cederroth, CR, Vinciguerra, M, Gjinovci, A, Kuhne, F, Klein, M, Cederroth, M, Caille, D, Suter, M, Neumann, D, James, RW, Doerge, DR, Wallimann, T, Meda, P, Foti, M, Rohner- Jeanrenaud, F, Vassalli, JD, Nef, S, (2008) Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes 57. 1176-1185. P
13. Vinciguerra, M, (2009) Aldosterone, but not increased Na+ influx or NF-kB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells. Horm. Metab. Res. 41. 67-70. P
14. Leroy, V, De Seigneux, S, Agassiz, V, Hasler, U, Rafestin-Oblin, ME, Vinciguerra, M, Martin, PY, Feraille, E, (2009) Aldosterone Activates the NF-κB Signaling Pathway via Mineralocorticoid Receptor in Physiologically Targeted Renal Tubule Epithelial Cells. J. Am. Soc. Nephr. 20. 131-144. (with Editorial) P
15. Vinciguerra, M, Sgroi, A, Veyrat-Durebex, C, Rubbia-Brandt, L, Buhler, LH, Foti, M, (2009) Unsaturated fatty acids inhibit the expression of tumor suppressor PTEN (phosphatase and tensin homolog) via microRNA-21 upregulation in hepatocytes. Hepatology. 49(4):1176-1184. P
16. Veyrat-Durebex, C, Montet, X, Vinciguerra, M, Gjinovci, A, Meda, P, Foti, M, Rohner-Jeanrenaud, F, (2009) The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue. Am. J. Physiol. Endocrin. Metab. 296(5): E1120-32. P
17. Vinciguerra, M, Carrozzino, F, Carlone, S, Montesano, R, Benelli, R, Foti, M, (2009) Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN. J. Hepatol. 50(6): 1132-41. P
18. Vinciguerra, M, Santini, MP, Claycomb, WC, Ladurner, AG, Rosenthal, N (2009) Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stress via SirT1 activity. Aging 2(1): 43-62. (Journal Cover and Commentary) P
19. Pazienza, V, Vinciguerra, M, Andriulli, A, Mangia, A (2010) HCV core protein genotype 3a increases SOCS-7 expression through PPAR-gamma in Huh-7 cells. J Gen Virol 91(Pt 7):1678-86. P
20. Zanchi, A, Maillard, M, Jornayvaz, FR, Vinciguerra, M, Deleaval, P, Nussberger, J, Burnier, M, Pechere-Bertschi, A (2010) Effects of PPAR-γ agonist pioglitazone on renal and hormonal responses to salt in hypertensive and diabetic subjects. Diabetologia 53(8):1568-75. P
21. Vinciguerra, M, Hede, M, Rosenthal, N (2010) Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 is a major regulator of muscle mass during growth but not for adult myofiber hypertrophy. J Appl Physiol. 108(6):1829-30. E
22. Vinciguerra, M, Fulco, M, Ladurner, A, Sartorelli, V, Rosenthal, N (2010) SirT1 in muscle physiology and disease: lessons from mice models. Dis Model Mech. 3(5-6): 298-303. (among the 20 most read articles on Dis Model Mech, since 2010 through September 2012) R
23. Vinciguerra, M, Musaro, A, Rosenthal, N (2010) Regulation of muscle atrophy in aging and disease. Adv Exp Med Biol. 2010; 694:211-33. R
24. Clément, S, Peyrou, M, Sanchez-Pareja, A, Bourgoin, L, Ramadori, P, Suter, D, Vinciguerra, M, Guilloux, K, Pascarella, S, Rubbia-Brandt, L, Negro, F, Foti, M (2011) Downregulation of PTEN and IRS-1 by HCV 3a core protein triggers the formation of large lipid droplets in hepatocytes. Hepatology 54(1): 38-49. P
25. Ripoli, M, Barbano, R, Parrella, P, Brunetti, V, Mazzoccoli, G, Fazio, VM, Andriulli, A, Vinciguerra, M, Pazienza, V (2011) Methylation profile of HCC-candidate genes in Huh-7 cells expressing the HCV core protein. Virus Res 160(1-2):74-81. P
26. Boon, RA, Seeger, T, Heydt, S, Fischer, A, Horrevoets, AJG, Vinciguerra, M, Rosenthal, N, Sciacca, S, Pilato, M, , van Heijningen, P, Essers, J, Brandes, RP, Zeiher, AM, Dimmeler, S. (2011) MicroRNA-29 in Aortic Aneurysm formation. Circ Res. 109(10):1115-9. (with Editorial and Journal Cover; among the 10 most read articles on Circ Res in 2011) P
27. Piepoli, A, Pazienza, V, Panza, A, Valvano, MR, Benegiamo, G, Vinciguerra, M, Andriulli, A, Mazzoccoli, G. (2011) SIRT1 and the clock gene machinery in colorectal cancer. Cancer Invest 30(2):98-105. P
28. Mazzoccoli, G, Sothern, RB, Greco, A, Pazienza, V, Vinciguerra M, Liu, S, Cai, Y (2011) Time-Related Dynamics of Variation in Core Clock Genes Expression Levels in Tissues Relevant to the Immune System. Int J Immunopathol Pharmacol. 24(4):869-79. P
29. Mazzoccoli, G, Pazienza, V, Panza, A, Valvano, MR, Benegiamo, G, Vinciguerra, M, Andriulli A, Piepoli, A (2012) ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer. J Cancer Res Clin Oncol 138(3):501-11. P
30. Vinciguerra, M, Santini, MP, Martinez, C, Pazienza, V, Claycomb, WC, Giuliani, A, Rosenthal, N (2012) mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart. Aging Cell 11(1):139-149 P
31. Mazzoccoli, G, Pazienza, V, Vinciguerra, M (2012) Clock genes and clock controlled genes in the regulation of metabolic rhythms. Chronobiol Int. 29(3):227-51. R
32. Deblon, N, Bourgoin, L, Veyrat-Durebex, C, Peyrou, M, Vinciguerra, M, Caillon, A, Maeder, C, Fournier, M, Montet, X, Rohner-Jeanrenaud, F, Foti, M (2012) Chronic mTOR inhibition induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol 165(7):2325-40. P
33. Sciacca, S, Pilato, M, Mazzoccoli, G, Pazienza, V, Vinciguerra, M (2013) Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. Heart Vessels 28(2):268-75 P
34. Tonkin, J, Villarroya, F, Puri, PL, Vinciguerra, M (2012) SIRT1 signaling as potential modulator of skeletal muscle diseases. Curr Opin Pharmacol 12(3):372-6. R
35. Fontana, L, Vinciguerra, M, Longo, VD (2012) Growth factors, adiposity and cardiovascular aging. Circ Res. 110:1139-1150. R
36. Benegiamo, G, Vinciguerra, M, Mazzoccoli, G, Andriulli, A, Pazienza, V, (2012) DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes. Dig Dis Sci. 57(6):1598-603 P
37. Bolasco, G, Calogero, R, Carrara, M, Al Banchaabouchi, M, Bilbao, D, Mazzoccoli, G, Vinciguerra, M, (2012) Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice. Aging 4(6):402-16. (with Editorial and Journal Cover) P
38. Vinciguerra, M, (2012) Targeting chromatin remodelers to treat hepatocellular carcinoma. Hepatology Jun 28. doi: 10.1002/hep.25925. [Epub ahead of print] E
39. Mazzoccoli, G, Francavilla, M, Giuliani, F, Aucella, F, Vinciguerra, M, Pazienza, V, Piepoli, A, Benegiamo, G, Liu, S, Cai Y, (2012) Clock gene expression in mouse kidney and testis: analysis of periodical and dynamical patterns. J Biol Regul Homeost Agents 26(2):303-11. P
40. Mazzoccoli, G, Cai, Y, Liu, S, Greco, A, Francavilla, M, Giuliani, F, Piepoli, A, Pazienza, V, Vinciguerra, M, Yamamoto, T, Takumi, T (2012) REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge. J Biol Regul Homeost Agents 26(2):265-76. P
41. Pazienza, V, Tavano, F, Benegiamo, G, Vinciguerra, M, Burbaci, FP, Copetti, M, di Mola, FF, Andriulli, A, Di Sebastiano, P (2012) Correlations among PPARγ, DNMT1 and DNMT3B expression levels and pancreatic cancer. PPAR Res 461784. Epub 2012 Aug 8. P
42. Planavila, A, Dominguez, E, Navarro, M, Vinciguerra, M, Iglesias, R, Giralt,M, Lope-Piedrafita, S, Ruberte, J,Villarroya, F, (2012) Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart. J Mol Cell Cardiol Aug 6. [Epub ahead of print] P
43. Pazienza, V, Vinciguerra, M, Mazzoccoli, G, (2012) PPARs signaling and cancer in the gastrointestinal system. PPAR Res 560846. Epub 2012 Sep 17. R
44. Mazzoccoli, G, Sothern, RB, Pazienza, V, Benegiamo, G, Muscarella, LA, Fazio, VM, Parrella, P, Vinciguerra, M, Tarquini, (2012) Hormone and Cytokine Circadian Alteration in Non Small Cell Lung Cancer Patients. Int J Immunopathol Pharmacol. 25(3):691-702 P
45. Podrini, C, Borghesan, M, Greco, A, Pazienza, V, Mazzoccoli, G, Vinciguerra, M, (2012) Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NALFD). Curr Pharm Des Oct 18. [Epub ahead of print] R
46. Mazzoccoli, G, Francavilla, M, Pazienza, V, Piepoli, A, Benegiamo, G, Vinciguerra, M, Giuliani, F, Yamamoto, T, Takumi, T (2012) Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach. Chronobiol Int 29(10):1300-11 P
47. Mazzoccoli, G, Longhitano, C, Vinciguerra, M (2013) Cardiohepatic metabolic derangements and valproic acid. Curr Clin Pharmacol Dec 6. [Epub ahead of print] R
48. Vinciguerra, M (2012) Old age and steatohepatitis: a dangerous liaison? Hepatology Dec 22. doi: 10.1002/hep.26212. [Epub ahead of print] E
49. Tevy, MF, Giebultowicz, J, Pintus, Z, Mazzoccoli, G, Vinciguerra, M (2013) Aging signalling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab Jan 5. doi:pii: S1043-2760(12)00221-4. 10.1016/j.tem.2012.12.002. [Epub ahead of print] R
50. Rizzo, M, Montalto, G, Vinciguerra, M (2013) Exploring lipid-related treatment options for the treatment of NASH. Curr Vasc Pharmacol Dec 28. [Epub ahead of print] E
51. Rappa, F, Greco, A, Podrini, C, Cappello, F, Foti, M, Bourgoin, L, Peyrou, M, Marino, A, Scibetta, N, Williams, R, Mazzoccoli, G, Federici, M, Pazienza, V, Vinciguerra, M (2013) Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PLOS ONE 10.1371/journal.pone.0054458 P
52. Anderson, G, Beischlag, TV, Vinciguerra, M*, Mazzoccoli, G* (2013) The circadian clock circuitry and the AHR signaling pathway in physiology and pathology. Biochem Pharmacol doi:pii: S0006-2952(13)00126-3. 10.1016/j.bcp.2013.02.022. R
* = equal contribution
53. Vinciguerra, M, Borghesan, M, Pazienza, V, Piepoli, A, Palmieri, O, Tarquini, R, Tevy, MF, De Cata, A, Mazzoccoli, G (2013) Transcriptional regulators, the circadian clock and the immune system. J Biol Regul Homeost Agents Jan;27(1):9-22.
54. Benegiamo, G, Vinciguerra, M, Guarnieri, V, Niro, G, Andriulli, A, Pazienza, V (2013) Hepatitis Delta Virus (HDV) induces specific DNA methylation events towards malignancy in hepatoma cells. FEBS Lett Mar 20. doi:pii: S0014-5793(13)00232-9. 10.1016/j.febslet.2013.03.021. P
55. Benegiamo, G, Mazzoccoli, G, Cappello, F, Rappa, F, Scibetta, N, Oben, J, Greco, A, Williams, R, Andriulli, A, Vinciguerra, M*, Pazienza, V*(2013) Mutual antagonism between circadian protein Period 2 and hepatitis C virus replication in hepatocytes. PLOS ONE 8(4):e60527. P
* = equal contribution and co-corresponding authors
56. Pazienza, V, Niro, G, Fontana, R, Vinciguerra, M, Andriulli, A (2013) Advance in molecular diagnostic tools for Hepatitis B Virus detection. Clin Chem Lab Med 6:1-11. doi: 10.1515/cclm-2013-0136. R
57. Vinciguerra, M, Tevy, MF, Mazzoccoli, G (2013) A ticking clock links metabolic pathways and organ systems function in health and disease. Clin Exp Med Apr 4. [Epub ahead of print]. R
58. Planavila, A, Redondo, I, Hondares, E, Vinciguerra, M, Munts, C, Iglesias, R, Gabrielli, L, Sitges, M, Giralt, M, van Bilsen, M, Villarroya, F (2013) Fibroblast growth factor-21 exerts a protective role against cardiac hypertrophy. Nat Commun 17 Jun 2013 doi: 10.1038/ncomms3019. P
59. Panza, A, Pazienza, V, Ripoli, M, Benegiamo, G, Gentile, A, Valvano, MR, Augello, B, Merla, G, Pratticizzo, C, Tavano, F, Ranieri, E, Di Sebastiano, P, Vinciguerra, M, Andriulli, Mazzoccoli, G, Piepoli, A (2013) Interplay between SOX9, Beta-catenin and PPAR-gamma activation in colorectal cancer. Biochim Biophys Acta 1833(8):1853-65. P
60. Mazza, T, Castellana, S, Andriulli, A, Auffray, C, Vinciguerra, M, Pazienza, V (2013) Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a. BioSystems 114(1):64-8. P
61. Bonny, O, Vinciguerra, M, Gumtz, M, Mazzoccoli, G (2013) Molecular bases of circadian rhythmicity in renal physiology and pathology. Nephrol Dial Transplant 2013 Jul 30. [Epub ahead of print] R
62. Sheedfar, F, Di Biase S, Koonen, DP, Vinciguerra M (2013) Liver diseases and aging: friends or foes?. Aging Cell Jul 1. doi: 10.1111/acel.12128. [Epub ahead of print] R
63. Sigala, B, McKee, C, Soeda, J, Pazienza, V, Morgan, M, Lin, CI, Selden, C, Vander Borght, S, Mazzoccoli, G, Roskams, T, Vinciguerra, M*, Oben, J* (2013) Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. PLOS ONE 8(9): e72928. P
* = equal contribution and co-corresponding authors
64. Mazzoccoli, G, De Cata, A, Piepoli, A, Vinciguerra, M (2013) The circadian clock and the hypoxic response pathway in kidney cancer. Tumor Biol Aug 14. [Epub ahead of print] P
65. Mazzoccoli, G, Tomanin, R, Mazza, T, D'Avanzo, F, Pazienza, V, Francavilla, M, Giuliani, F, Vinciguerra, M, Scarpa, M (2013) Circadian gene expression and impact of iduronate-2-sulfatase treatment in human fibroblasts from Hunter syndrome. BMC Medical Genomics 6(1):37. P
66. Mazzoccoli, G, Tevy, MF, Borghesan, M, Delle Vergini, MR, Vinciguerra, M (2014) Caloric restriction and aging stem cells: the stick and the carrot? Exp Gerontol 50:137-48. R
67. Vinciguerra, M, Mazzoccoli, G, Piccoli, C, Tataranni, T, Andriulli, A, Pazienza, V (2013) Exploitation of host clock gene machinery by hepatitis viruses B and C. World J Gastroenterol 19(47):8902 -8909 R
68. Vinciguerra, M (2014) Normalization of a NAFLD gene expression signature. Hepatology Feb 3. doi: 10.1002/hep.27042. E
69. Pazienza, V, Borghesan, M, Mazza, T, Sheedfar, F, Panebianco, C, Williams, R, Mazzoccoli, G, Andriulli, A, Nakanishi, T, Vinciguerra, M (2014) SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation. Aging Jan 28. [Epub ahead of print] P
70. Mazzoccoli, G, Vinciguerra, M, Papa, G, Piepoli, A (2014) The circadian clock circuitry in colorectal cancer. World J Gastroenterol 20(15):4197-4207. R
71. Carter, R, Mouralidarane, A, Soeda, J, Ray, S, Pombo, J, Saraswati, R, Novelli, M, Fusai, G, Rappa, F, Saracino, C, Pazienza, V, Poston, L, Taylor, PD, Vinciguerra, M, Oben, JA (2014) Non-Alcoholic Fatty Pancreas Disease Pathogenesis: A Role for Developmental Programming and Altered Circadian Rhythms. PLOS ONE a9(3):e89505 P
72. de Matthaeis, A, Greco, A, Dagostino, MP, Paroni, G, Fontana, G, Vinciguerra, M, Mazzoccoli, G, Seripa, D, Vendemiale, G (2014) Hypercapnia-induced effects on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease. Clin Interv Aging 29;9:871-8. P
73. Panza, A, Votino, C, Gentile, A, Valvano, MR, Colangelo, T, Pancione, P, Merla, G, Andriulli, A, Sabatino, L, Vinciguerra, M, Pratichizzo, C, Mazzoccoli, G, Colantuoni, V, Piepoli, A (2014) Proliferator-Activated Receptor -mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. Biochim Biophys Acta 1843(6):1225-1236. P
74. Mazzoccoli, G, Vinciguerra, M, Oben, J, Tarquini, R, De Cosmo, S (2014) Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity. Liver Int Mar 20. doi: 10.1111/liv.12534. [Epub ahead of print]R
75. Sheedfar, F, Sung, M, Aparicio-Vergara, M, Kloosterhuis, N, Miquilena-Colina, ME, Vargas-Castrillón, J, Febbraio, M, Jacobs, R, de Bruin, A, Vinciguerra, M, García-Monzón, C, Hofker, M, Dyck, J, Koonen D (2014) Increased Hepatic CD36 Expression with Age is Associated with Enhanced Susceptibility to Nonalcoholic Fatty Liver Disease. Aging Apr 9. [Epub ahead of print] P
76. Vinciguerra, M (2014) Protein intake, chronic liver diseases and hepatocellular carcinoma. Hepatology Jun 13. doi: 10.1002/hep.27260. E
77. Sheedfar, F, Vermeer, M, Pazienza, V, Villarroya, J, Rappa, F, Cappello, F, Villarroya, F, van der Molen, H, Hofker, M, Koonen, D, Vinciguerra, M (2014) Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high fat diet. Int J Obes May 21. doi: 10.1038/ijo.2014.91. [Epub ahead of print] P
78. Borghesan, M, Mazzoccoli, G, Sheedfar, F, Oben, J, Pazienza, V, Vinciguerra, M (2014) Histone variants and lipid metabolism. Biochem Soc Trans 42(5):1409-13. R
79. Pazienza, V, Pomara, C, Cappello, F, Calogero, R, Carrara, M, Mazzoccoli, Vinciguerra, M (2014) TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling. Am J Physiol Heart Circul Physiol Aug 8. pii: ajpheart.00150.2014. [Epub ahead of print] P
80. Mazzoccoli, G, Mazza, T, Vinciguerra, M, Castellana, M, Scarpa, M (2015) The biological clock and the molecular basis of lysosomal storage diseases. J Inherit Metab Dis [Epub ahead of print] R
81. Vinciguerra, M (2014) Nitric oxide as a protector from NAFLD. Hepatology Oct 12. doi: 10.1002/hep.27562. [Epub ahead of print] E
82. Mazzoccoli, G*, Dagostino, MP, Vinciguerra, M*, Ciccone, F, Paroni, G, Seripa, D, Addante, F, Montella, RC, De Cosmo, S, Sera, F, Greco, A (2014) An association study between epicardial fat thickness and cognitive impairment in the elderly Am J Physiol Heart Circul Physiol Aug 29. pii: ajpheart.00175.2014. [Epub ahead of print] P
* = co-corresponding authors
83. Tavano, F, Fontana, A, Pellegrini, F, Burbaci, FP, Rappa, F, Cappello, F, Copetti, M, Maiello, E, Lombardi, L, Graziano, P, Vinciguerra, M, di Mola, FF, di Sebastiano, P, Andriulli, A, Pazienza, V (2014) Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients. J Transl Med 12(1):248. P
84. Maugeri, A, Barchitta, M, Quattrocchi, A, Vinciguerra*, M, Agodi, A* (2014) LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis. PLOS ONE 9(10):e109478. P
*=co-corresponding authors
85. Tavano, F, Pazienza, V, Fontana, F, Burbaci, FP, Panebianco, C, Saracino, C, Lombardi, L, De Bonis, A, di Mola, FF, di Sebastiano, P, Piepoli, A, Vinciguerra, M, Francavilla, M, Giuliani, G, Andriulli, A, Mazzoccoli, A (2015) SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma and effect of starvation in pancreatic cancer cell lines Chronobiol Int Mar 23:1-16. [Epub ahead of print] P
86. Fontana, L, Antebi, A, Bartke, A, Barzilai, N, Brown-Borg, H, Curiel, T, De Cabo, R, Franceschi, C, Gems, D, Ingram, D, Lepperdinger, G, Johnson, T, Kennedy, B, Kenyon, C, Klein, S, Kopchick, J, Madeo, F, Mirisola, M, Mitchell, J, Passarino, G, Rudolph, KL, Sedivy, J, Shadel, G, Sinclair, D, Spindler, S, Suh, Y, Vijg, V, Vinciguerra, M, Longo VD (2015) Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14(4):497-510. R
87. Sanjabi, B, Dashty, M, Ozcan, B, Akbarkhanzadeh, V, Rahimi, M, Vinciguerra, M, De Rooij, F, Lahham, S, Sheedfar, F, Spek, CA, van Kooten, TG, Rowshani, A, Van der Want, J, Klaassen, R, Sijbrands, E, Peppelenbosch, M, Rezaee F (2015) Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes Sci Rep5:8816. P
88. McKee, C, Sigala, B, Soeda, J, Mouralidarane, A, Morgan, M, Mazzoccoli, G, Rappa, F, Cappello, F, Cabibi, D, Pazienza, V, Selden, C, Roskams, T, Vinciguerra M*$, Oben, J* (2015) Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis Sci Rep 5:8812 P
*=co-senior authors $=corresponding author
89. Podrini, C, Koffas, A, Chokshi, S, Vinciguerra, M, Lelliott, CJ, White, JK, Adissu, HA, Williams, R, Greco, A (2014) MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB J Dec 19. pii: fj.14-262717. [Epub ahead of print] P
90. Brandhorst, S, Choi, I, Cheng, CW, Wei, M, Sedrakyan, S, Navarre, G, Dubeau, L, Peng Yap, L, Park, R, Vinciguerra, M, Di Biase, S, Mirzaei, H, Childress, P, Ji, L, Groshen, S, Penna, F, Odetti, P, Perin, L, Conti, PS, Ikeno, Y, Kennedy, BK, Cohen, P, Morgan, TE, Longo, VD (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism Jun 17. pii: S1550-4131(15)00224-7. doi: 10.1016/j.cmet.2015.05.012. [Epub ahead of print] P
91. Mouralidarane, A, Soeda, J, David Sugden, Bocianowska, A, Carter, R, Ray, S, Saraswati, R, Cordero, P, Novelli, M, Fusai, G, Vinciguerra, M,* Poston, L, Taylor, P, Oben, J (2015). Maternal Obesity Programs Offspring Non-Alcoholic Fatty Liver Disease through disruption of 24-hours Rhythms in Mice . Int J Obes May 14. doi: 10.1038/ijo.2015.85. [Epub ahead of print] P
*=corresponding author
92. D’Aronzo, M*, Vinciguerra, M*, Mazza, T, Panebianco, C, Saracino, C, Pereira, SP, Graziano, P, Pazienza, V (2015) Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models. Oncotarget 6(21):18545-57. P
*=equal contribution
93. Vinciguerra, M*, Mazzoccoli, G (2015) AHR-FGF21 dissociation of fatty liver from insulin resistance: a timely matter?. Hepatology Jun 25. doi: 10.1002/hep.27958. [Epub ahead of print]E
*=corresponding author
94. Mazzoccoli, G, Tarquini, R, Valoriani, A, Oben, J, Vinciguerra, M, Marra, F (2015) Management strategies for hepatocellular carcinoma: old certainties and new realities. Clin Exp Med Jun 16. [Epub ahead of print] R
95. Agodi, A, Barchitta, M, Quattrocchi, A, Maugeri, A, Canto, C, Marchese, AE, Vinciguerra, M (2015) Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes & Nutrition 10(5):480. P
96. Rahimi, M*, Vinciguerra, M*, Mojtaba, D, Ozcan, Akbarkhanzadeh, V, B, Sheedfar, F, Amini, M, Mazza, T, Pazienza, V, Motazacher, MM, Mahmoudi, M, Derooij, F, Sijbrands, E, Peppelenbosch, M, Rezaee, F (2015) Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. Oncotarget Aug 13. doi: 10.1111/jgh.13085. [Epub ahead of print]P
=*equal contribution
97. Morgan, ML, Sigala, B, Soeda, J, Cordero, P, Nguyen, V, McKee, C, Mouraliderane, A, Vinciguerra, M*, Oben, JA (2015) Acetylcholine Induces Fibrogenic Effects via M2/M3 ACh Receptors in NASH and in Primary Human Hepatic Stellate Cells. J Gastroenterol Hepatol Aug 13. doi: 10.1111/jgh.13085. [Epub ahead of print]P
*=corresponding author
98. Agodi, A, Barchitta, M, Quattrocchi, A, Maugeri, A, Vinciguerra, M (2015) DAPK1 promoter methylation and cervical cancer risk: a systematic review and a meta-analysis. PLOS ONE 10(8):e0135078. P
99. Mazza, T, Fusilli, C, Saracino, C, Mazzoccoli, G, Vaccaro, M, Tavano, F, Vinciguerra, M, Pazienza, V (2015) Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines. IEEE Journal of Biomedical and Health Informatics May-Jun;12(3):667-78. P
100. Demolli, S, Doebele, Doddaballapur, A, Lang, V, Fisslthaler, B, Chavakis, E, Vinciguerra, M, Sciacca, S, Henschler, R, Hecker, M, Savant, S, Augustin, HG, Kaluza, D, Dimmeler, S, Boon, RA (2015) microRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of Angiopoietin 2. J Mol Cell Cardiol 88:111-119. P
101. Rahimi, M, Ng, EP, Bakhtiari, K, Vinciguerra, M, Ahmad, HA, Awala, H, Mintova, S, Daghighi, S, Bakhshande, S, de Vries, M, Motazacker, M, Peppelenbosch, MM, Mahmoudi, M, Rezaee, F (2015) Nanosized Zeolite Nanoparticles for Selective Sorption of Plasma Proteins. Sci Rep 5:17259. P
102. Mazzoccoli, G, Miele, L, Grieco, A, Vinciguerra, M (2015) Biology, epidemiology, clinical aspects of hepatocellular carcinoma and the role of Sorafenib. Curr Drug Targets Dec 9. [Epub ahead of print] R
103. Mazzoccoli, G, Laukkanen, MO, Vinciguerra, M, Colangelo, T, Colantuoni, V (2016) A Timeless link between circadian patterns and disease Trends Mol Med 22(1):68-81. R
104. Borghesan, M, Fusilli, C, Rappa, F, Panebianco, C, Rizzo, G, Oben, JA, Mazzoccoli, G, Faulkes, C, Pata, I, Agodi, A, Rezaee, F, Minogue, S, Warren, A, Peterson, A, Sedivy, JM, Douet, J, Buschbeck, M, Cappello, F, Mazza, T, Pazienza, V, Vinciguerra, M (2016) DNA hypomethylation and histone variant macroH2A1 synergistically attenuate chemotherapy-induced senescence to promote hepatocellular carcinoma progression. Cancer Res 76(3):594-606. P
105. Mazzoccoli, G, Rubino, R, Tiberio, C, Giuliani, F, Vinciguerra, M, Oben, J, De Cata, A, Tarquini, R, De Cosmo, S, Liu, S, Cai, Y (2016) Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation. Chronobiol Int 33(2):181-90. P
106. Soeda, J, Mouralidarane, A, Cordero, P, Li, J, Nguyen, V, Carter, R, Kapur, SR, Pombo, J, Poston, Taylor, PD, Vinciguerra, M*, Oben, JA,* (2016) Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem 72(2):281-91. P
=*equal contribution
107. Jueliger, S, Lyons, J, Cannito, S, Pata, I, Pata, P, Shkolnaya, M, Lo Re, O, Peyrou, M, Villarroya, F, Pazienza, V, Rappa, F, Cappello, F, Azab, M, Taverna, P, Vinciguerra, M (2016) Efficacy and epigenetic interactions of novel DNA hypomethylating agent Guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. Epigenetics Aug 11:1-12.P
108. Buchan, I, Furini, G, Lortat-Jacob, H, Scarpellini, A, Schroeder, N, Maamra, M, Watson, P, Vinciguerra, M, Johnson, TS, Verderio, EA (2016) Interplay between transglutaminases and heparan sulphate in progressive renal scarring. Sci Rep 6:31343. P
109. Panebianco, C, Vinciguerra, M, Pazienza, V (2016) Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signaling. Clin Exp Med Sep 21. [Epub ahead of print] R
110. Pazienza, V, Panebianco, C, Rappa F, Memoli, D, Borghesan, M, Cannito, S, Oji, A, Mazza, G, Tamburrino, M, Fusai, G, Barone, R, Bolasco, G, Villarroya, F, Villarroya, J, Hatsuzawa, K, Cappello, F, Tarallo, R, Nakanishi, T, Vinciguerra, M (2016) Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis. Epigenetics & Chromatin Oct 25;9:45. P
111. Balasus, D, Way, M, Fusilli, C, Mazza, T, Morgan, MY, Cervello, M, Giannitrapani, L, Soresi, M, Agliastro, R, Vinciguerra, M, Montalto, G (2016) The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population. Oncotarget Nov 24. doi: 10.18632/oncotarget.13558. [Epub ahead of print] P
112. Soeda, J, Cordero, P, Li, J, Mouralidarane, A, Asilmaz, E, Ray, S, Nguyen, V, Carter, R, Novelli, M, Vinciguerra, M, Poston, L, Taylor, PD, Oben, JA (2016) Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high fat diet-induced obesity. Int J Food Sci Nutr Nov 29:1-12. [Epub ahead of print] P
113. Shim, HS, Di Biase, S, Lee, C, Vinciguerra, M, Rappa, F, Wei, M, Brandhorst, S, Cappello, S, Longo VD (2017) Fasting Regulates EGR1 and Protects from Glucose-and Dexamethasone Dependent Sensitization to Chemotherapy. PLOS Biol 15(5):e1002603. P
114. Lo Re, O, Panebianco, C, Porto, S, Cervi, C, Rappa, F, Di Biase, S, Caraglia, M, Pazienza, V, Vinciguerra, M (2017) Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells. J Cell Physiol.doi: 10.1002/jcp.25987. [Epub ahead of print] P
115. Li Volti, G, Avola, R, Vinciguerra, M (2017) Commentary: Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Front Oncol Jun 2;7:116. E
116. Pindjakova, P, Sartini, C, Lo Re, O, Rappa, F, Coupe, B, Lelouvier, B, Pazienza, V, Vinciguerra, M (2017) Gut dysbiosis and adaptive immune response in diet-induced obesity versus systemic inflammation. Front Microbiol Jun 22;8:1157. P
117. Bellanti, F, Iannelli, G, Blonda, M, Tamborra, R, Villani, R, Romano, A, Calcagnini, S, Mazzoccoli, G, Vinciguerra, M, Gaetani, S, Giudetti, AM, Vendemiale, G, Cassano, T, Serviddio, G (2017) Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease. J Alzheimers Dis Jun 24. doi: 10.3233/JAD-160942. [Epub ahead of print]
118. Movsisyan*, NK, Vinciguerra, M*, Kunzová, S, Homolka, M, Jaresova, J, Cifkova, R, Lopez-Jimenez, F, Sochor, O (2017) Kardiovize Brno 2030, a prospective cardiovascular health study in Central Europe: methods, baseline findings and future directions. Eur J Prev Cardiol Jan 1:2047487317726623. doi: 10.1177/2047487317726623. [Epub ahead of print]P
=*equal contribution
119. Lo Re, O, Fusilli, C, Rappa, F, Van Haele, M, Douet, F, Pindjakova, J, Rocha, SW, Pata, I, Valčíková, B, Uldrijan, S, Yeung, RS, Peixoto, CA, Roskams, T, Buschbeck, M, Mazza, T, Vinciguerra, M (2017) Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma. Hepatology Sep 15. doi: 10.1002/hep.29519. [Epub ahead of print] P
120. Cordero, P, Li, J, Nguyen, V, Pombo, J, Maicas, N, Novelli, M, Taylor, PD, Samelsson, AM, Vinciguerra, M, Oben, JA (2017) Developmental programming of obesity and liver metabolism by maternal perinatal nutrition involves the melanocortin system. Nutrients Sep 20;9(9). pii: E1041. P
121. Lo Re, O, Vinciguerra, M (2017) Histone macroH2A1: a chromatin point of intersection between fasting, senescence and cellular regeneration. Genes 8(12), 367 R
122. Vinciguerra, S, Vinciguerra, M (2018) Smart devices and healthy aging. Nutr Healthy Aging 10.3233/NHA-170039, pp 1-7 R
123. Maugeri, A, Oben, JA, Vinciguerra, M (2018) Protein-rich or amino-acid only diets entrain the liver CLOCK: time to scrap insulin? EBioMedicine 28:9-10. E
124. Maugeri, A, Kunzova, S, Medina, J, Agodi, A, Barchitta, M, Homolka, M, Kiacova, N, Bauerova, H, Sochor, O, Lopez-Jimenez, F, Vinciguerra, M (2018) Association between Eating Time Interval and Frequency with Ideal Cardiovascular Health: Results from a Random Sample Czech Urban Population. Nutr Metab Cardiovasc Dis pii: S0939-4753(18)30123-6. doi: 10.1016/j.numecd.2018.04.002. P
125. Hruskova, H, Maugeri, A, Podroužková, H, Štípalová, T, Jakubík, J, Barchitta, M, Medina-Inojosa, JR, Homolka, M, Agodi, A, Kunzova, S, Sochor, O, Lopez-Jimenez, F, Vinciguerra, M (2018) Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: the Kardiovize study. J Clin Med 7(5). pii: E113. doi: 10.3390/jcm7050113 P
126. Maugeri, A, Mazzone, M.G., Giuliano, F, Vinciguerra, M, Basile, G, Barchitta, Agodi, A (2018) Curcumin modulates DNA methyltransferases functions in a cellular model of diabetic retinopathy. Oxid Med Cell Longev 2018:5407482. doi: 10.1155/2018/5407482. P
127. Agodi, A, Maugeri, A, Kunzova, S, Sochor, O, Bauerova, H, Kiacova, N, Barchitta, M, Vinciguerra, M (2018) Association of Dietary Patterns with Metabolic Syndrome: Results from the Kardiovize Brno 2030 Study. Nutrients 10, 898. P
128. Lo Re, O, Douet, J, Buschbeck, M, Fusilli, C, Pazienza, V, Panebianco, C, Castruccio Castracani, C, Mazza, T, Li Volti, G, Vinciguerra, M (2018) Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells. Epigenetics Aug 30. doi: 10.1080/15592294.2018.1514239. [Epub ahead of print] P
129. Maugeri, A, Medina-Inojosa, J.R., Kunzova, S, Agodi, A, Barchitta, M, Sochor, O, Lopez-Jimenez, F, Geda, Y.E., Vinciguerra, M (2018) Sleep Duration and Excessive Daytime Sleepiness are Associated with Obesity Independent of Diet and Physical Activity. Nutrients accepted P
130. Bienertova-Vasku, J, Vinciguerra, M, Buzga, M, Villarroya, F (2018) Adipokines as Biomarkers in Health and Disease. Disease Markers accepted E
131. Kovacovicova, K, Skolnaja, M, Mistrik, M, Heinmaa, M, Pata, P, Pata, P, Bartek J, Vinciguerra, M (2018) Senolytic cocktail dasatinib+quercetin (D+Q) does not enhance the efficacy of senescence-inducing chemotherapy in liver cancer. Front Oncol accepted P

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PhD Thesis
“Mechanisms of control of Na,K-ATPase expression by intracellular Na+ in kidney collecting duct principal cells.” Published in 2004, University of Geneva, Switzerland.

Book Edited
Molecular Nutrition: Mother and Infant 1st Edition
by Manlio Vinciguerra (Editor), Paul Cordero Sanchez (Editor)
Paperback: 768 pages
Publisher: Academic Press; 1 edition (August 15, 2019)
Language: English
ISBN-10: 0128138629
ISBN-13: 978-0128138625

Book Chapters
1. Vinciguerra Manlio, Musaro Antonio, Rosenthal Nadia (2010): “Regulation of muscle atrophy in muscle ageing and disease: the IGF-1 system”, in Protein Metabolism and Homeostasis in Aging. Edited by Nektarios Tavernarakis, Landes Bioscience, Austin, Texas, USA.
2. Vinciguerra Manlio, Lionetti Vincenzo, Ventura Carlo, Rosenthal Nadia (2012): “Cardiac versus non-cardiac stem cells to repair the heart: the role of autocrine/paracrine signals”, in Advances in Stem Cell Research, Stem Cell Biology and Regenerative Medicine, 2012, 367-382. Edited by Hossein Baharvand, Humana Press – Springer.
3. Feraille, E, Mordasini, D, Gonin, S, Deschenes, G, Vinciguerra, M, Doucet, A, Vandewalle, A, Summa, V, Verrey, F, Martin, P.Y (2002). Conference: 10th International Conference on Na,K-ATPase and Related Cation Pumps. Location: ELSINORE, DENMARK Date: AUG 08-14, 2002. Source: NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS Book Series: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Published: 2003
4. Simone Jueliger, Pietro Taverna, Oriana Lo Re, Manlio Vinciguerra. DNA demethylating senescence inducing drug to treat solid tumours. Handbook in Immunosenescence. Editors: Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec. Edited by Springer.2017
5. Oriana Lo Re, Manlio Vinciguerra. Sarcopenia and Parkinson's disease: molecular mechanisms and clinical management. In: Sarcopenia: Molecular, Cellular, and Nutritional Aspects. Editor: Dominique Meynial-Denis. Edited by CRC Press, Taylor & Francis Group. 2017

Publications not indexed on Pubmed/Medline (but on Scopus etc)
1. Vinciguerra, M (2008) Protein kinases and phosphatases as drug targets to cure human malignancies. Capsula Eburnea 3(5): 1-9.
2. Vinciguerra, M (2011) Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat. Endocrinology Studies 1(e4): 14-17.
3. Vinciguerra, M (2013) Paracrine mechanisms, signaling and epigenetics in repairing damaged tissue. Recent Patents on Regenerative Medicine (RPRM).
4. Planavila, A, Villarroya, F, Vinciguerra, M (2014). Nutrient signalling and cardiovascular aging. Heart and Metabolism. Issue 63.
5. Lo Re, O, Vinciguerra, M (2016). Macrohistone H2A1 takes the center stage in cancer research as a regulator of stemness. Translational Cancer Research Vol 5, Supplement 4.
6. Auffray, C, Sagner, M, Abdelhak, S, Adcock, I, Agusti, A, Amaral, M, Antonarakis, S, Arena, R, Argoul, F, Balling, R, Barabasi, AL, Beckmann, J, Bjartell, A, Blomberg, N, Bourgeron, T, Boutron, B, Brahmachari, S, Bréchot, C, Brightling, C, Cascante, M, Cesario, A, Charron, D, Chen, SJ, Chen, Z, Chung, F, Clément, K, Conesa, A, Cozzone, A, de Jong, M, Deleuze, JF, Demotes, J, di Meglio, A, Djukanovic, R, Dogrusoz, U, Epel, E, Fischer, A, Gelemanovic, A, Goble, C, Gojobori, T, Goldman, M, Goossens, H, Gros, F, Guo, YK, Hainaut, P, Harrison, D, Hoffmann, H, Hood, L, Hunter, P, Jacob, Y, Kitano, H, Klingmüller, U, Knoppers, B, Kolch, W, Koopmans, M, Lancet, D, Laville, M, Lehn, JM, Lévi, F, Lisistsa, A, Lotteau, V, Magnan, A, Mayosi, Bo, Metspalu, A, Moreau, Y, N’Dow, J, Nicod, L, Noble, D, Manuela Nogueira, M, Norrby-Teglund, A, Nottale, L, Openshaw, P, Oztürk, M, Palkonen, S, Parodi, S, Pellet, J, Polasek, O, Price, N, Pristipino, C, Radstake, T, Raes, M, Roca, J, Rozman, D, Sabatier, P, Sasson, S, Schmeck, B, Serageldin, I, Simonds, A, Soares, B, Sterk, P, Superti-Furga, G, Supple, D, Tegner, J, Uhlen, M, van der Werf, S, Villoslada, P, Vinciguerra, M, Volpert, V, Webb, S, Wouters, E, Sanz, F, Nobrega, F (2017) Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing. Progress in Preventive Medicine Volume 2 - Issue 3 - p e006.

Name and country Role Time spent Institution
Irma Magaly Rivas-Serna (Mexico) Postdoctoral researcher 2018 - ICRC
Sebastiano Giallongo (Italy) Ph.D student 2018 - ICRC
Jan Frohlich, Ph.D(Czech Republic) Postdoctoral researcher 2018 - ICRC
Maria Skladana, MD (Slovak Republic) Medical Doctor 2017- ICRC
Kristina Kovacovikova, Ph.D(Slovak Republic) Postdoctoral researcher 2017- ICRC
Andrea Maugeri (Italy) Medical Writer 2017- ICRC/University of Catania
Kamila Koci(Czech Republic) Senior Postdoctoral Researcher 2018- ICRC
Iuliia Pavlovska (Ukraine) PhD student 2018 - ICRC
Oriana Lo Re (Italy) Ph.D student 2016 - ICRC
Katka Gargulova (Czech Republic) Technician 2016 - ICRC
Jana Bartonova (Czech Republic) Technician 2016 - ICRC
Narine Movsisyan, MD(Armenia) Senior Postdoctoral Researcher 2017- ICRC
MUDr. Pavel Homolka, Ph.D.(Czech Republic)Postdoctoral Researcher 2017- ICRC
Ing. Martin Homolka Ph.D. (Czech Republic)Student 2017- ICRC
Ing. Jana Hrušková Ph.D. (Czech Republic)Post-doctoral researcher 2017 - ICRC
Ing. Juraj Jakubik Ph.D. (Czech Republic)Student 2018 - ICRC
MUDr. Šárka Kunzová Ph.D. (Czech Republic)Post-doctoral researcher 2017- ICRC
Hana Bauerová (Czech Republic)Research Nurse 2017- ICRC
Hana Krištofová Pernicová(Czech Republic) Research Nurse 2017- ICRC
Mgr. Pavlína Prosecká(Czech Republic) Research Nurse/Study Coordinator 2017- ICRC
Alena Zajíčková(Czech Republic) Research Nurse 2017- ICRC
Mgr. Jana Jarešová(Czech Republic) Study Coordinator 2017- ICRC
Sebastiano Giallongo Erasmus student (2 months)- University of Catania
Alberto Patane'Erasmus student (2 months)- University of Catania
Ing. Nikola Kiácová Ph.D. (2 years) ICRC
Ing. Hana Ross, Ph.D. Senior Postdoctoral Researcher 2012-2017- ICRC
MUDr. Robert Prosecký Ph.D. Student 2012-2017- ICRC
MUDr. Jiří Lešovský Ph.D. Student 2012-2016 ICRC
Kamilla Malinowska-Ozdowy (Poland) Post-doc Research Fellow 2016 (1 year) - ICRC
Antonio Pompeiano (Italy) Post-doc Research Fellow 2017 (8 months)- ICRC
Jana Pindjakova (Slovak Republic) Post-doc Research Fellow 2016 (16 months) - ICRC
Eva Gosposova (Czech Republic) Technician 2016 (6 months) - ICRC
Kamila Gajduskova (Czech Republic) Technician 2016 (8 mesi) - ICRC
Mgr. Martin Čuta, Ph.D. Senior Postdoctoral Researcher 2014-2016 (2 years) ICRC
Sara Cannito (Italy) Tech 2015- 2016 (8 mths) IRCCS CSS/UCL
Cecilia Morsilli (Italy) Tech 2015- 2016 (6 mths) University of Siena/UCL
Nadege Nziza (Ruanda/Belgium) BSc 2015 (2 mths) UCL/University of Namur
Almabrook Saeed (Lybia) MSc 2015 (4 mths) Nottingham Trent University
Sara Lopes (Portugal) MSc 2015 (4 mths) Nottingham Trent University
Stefania Porto (Italy) visiting PhD 2014-2015 (1 year) UCL/University of Naples
Michela Borghesan (Italy) MSc 2012-2015 (3 years) IRCCS CSS/UCL
Alessandra Warren (Italy/Australia) Fellow 2014 (4 mths) UCL/University of Sidney
Anna Humber (UK) MSc 2014 (3 mths) UCL
Carlo Cervi (Italy) MSc 2014 (3 mths) UCL
Chiara Montella (Italy) Fellow 2014 (2 mths) UCL
Fulvio Barone (Italy) MSc 2013 (2 mths) UCL
Daniele Balasus (Italy) visiting PhD 2013 (3 mths) UCL/University of Palermo
Fareeba Sheedfar (Iran/Dutch) visiting PhD 2012 (3 mths) Institute of Hepatology/UMCG
Azzura Greco (Italy) Tech 2011-2012 (1 year) Institute of Hepatology
Christine Podrini (Malta) MPhil 2011-2012 (1 year) Institute of Hepatology

Daniele Balasus (2014) University of Palermo, Italy
Andrew Holmes (2015) University of Liverpool, UK
Riccardo Ferro (2015) Queen Mary University, London, UK
Daniela Gnani (2015) University of Rome Tor Vergata, Italy,
Sarah Idri (2016) Nottingham Trent University (UK)/University of Tubingen (Germany),
Maitane Núñez García (2016) University of Basque Country, Bilbao, Spain
Urmo Vosa (2016) University of Tartu, Tartu, Estonia
Andrea Maugeri (2016) University of Catania, Catania, Italy
Maira Di Tano (2018) IFOM Istituto FIRC di Oncologia Molecolare, Milan, Italy
David William Mac Gillavry (2018) University of Defence, Brno, Czech Republic